4-Aminobutyraldehyde as a Substance Convertible In Vivo to GABA |
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| Authors: | Masakazu Sugahara Tadashi Asakura Susumu Kurioka Makoto Matsuda |
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| Affiliation: | Department of Biochemistry, The Jikei University School of Medicine, Tokyo, Japan |
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| Abstract: | Abstract: [2,3-3H]4-Aminobutyraldehyde ([3H]ABAL) was injected subcutaneously into mice, which were sacrificed at various intervals following injection. [3H]γ-Aminobutyric acid ([3H]GABA) synthesized in vivo from [3H]ABAL was extracted from the brains, separated, and quantitated. The results showed that in the brain, injected [3H]ABAL was rapidly transformed into [3H]GABA. [3H]ABAL may penetrate the blood-brain barrier into the central nervous system and then be oxidized to [3H]GABA. |
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| Keywords: | γ-Aminobutyric acid 4-Aminobutyraldehyde Prodrug |
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