Ornithine decarboxylase in Paracoccidioides brasiliensis |
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Authors: | Gioconda San-Blas Françoise Sorais Felipe San-Blas José Ruiz-Herrera |
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Institution: | (1) Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Microbiología y Biología Celular, Apartado 21827, Caracas 1020A, Venezuela Fax: +58-2-501-1382/572-7446 e-mail: gsanblas@ivic.ivic.ve/gcunto@dino.conicit.ve, VE;(2) Centro de Investigación y de Estudios Avanzados (CINVESTAV) del IPN, Departamento de Ingeniería Genética, Unidad Irapuato, Irapuato, Gto, Mexico, MX |
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Abstract: | Ornithine decarboxylase in Paracoccidioides brasiliensis, a dimorphic human pathogenic fungus, was more active at 37° C in the yeast phase and at 30° C in the mycelial phase. In
contrast to other fungal systems, yeast growth and mycelium-to-yeast transition in P. brasiliensis were accompanied by a high activity of ornithine decarboxylase at the onset of the budding process, the activity of which
was inhibited by 1,4-diamino-2-butanone. The activity of ornithine decarboxylase remained at a basal level during vegetative
growth of both the mycelial phase and the late stage of yeast phase, and also through the yeast-to-mycelium transition.
Received: 18 December 1995 / Accepted: 8 March 1996 |
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Keywords: | Paracoccidioides brasiliensis Fungal dimorphism Ornithine decarboxylase |
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