Gas chromatography in anaesthesia: I. A brief review of analytical methods and gas chromatographic detector and column systems

Practical applications and relevant studies involving the anaesthetic gases, have been extensively described in the literature. Many eminent analytical methods have already been developed for medical practice where routine analysis of anaesthetics is frequently needed, particularly during anaesthesia, and in related and respiratory research programmes. The determination of halothane, isoflurane, enflurane and nitrous oxide concentrations from vaporizers, in exhaled and inhaled gas mixtures, in body fluids and tissues is necessary to control anaesthetic concentrations, and thus, the relevant and adverse effects successfully. Therefore, a literature review, with particular emphasis on gas chromatography would provide important information for investigators in the search for a suitable analytical method for the analysis of multi-component mixtures of anaesthetic gases.