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| Study on Embryo-Fetal Development to Artesunate in Rats | |
| 作者姓名： | Moon-Koo Chung Jong-Choon Kim |
| 作者单位： | Korea Institute of Toxicology，KRICT，Daejeon 305-600 Korea，College of Veterinary Medicine，Chonnam National University，Gwangju 500-575，Korea |
| 摘 要： | The present study was conductedtoinvestigate the potential embryo-fetal toxicity of Artesunate,an antimalarial drug,inSprague-Dawleyrats.Thetestitemwas orallyadministered bygavageto pregnant rats(22females per group)fromgesta-tional day(GD)6through15at doselevels of0,2,4and8mg/kg,All dams were subjectedtocaesareansectionon GD20andtheir fetuses were examined for external,visceral,and skeletal abnormalities.There were no treatment-relatedclinical signs,body weights andfood consumptionin any o… |
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