| 兽疫链球菌荚膜多糖对免疫抑制鼠的抗氧化和免疫调节活性研究 |
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| 引用本文： | 柯春林,乔德亮,曾晓雄.兽疫链球菌荚膜多糖对免疫抑制鼠的抗氧化和免疫调节活性研究[J].中国微生态学杂志,2011,23(8):684-688. |
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| 作者姓名： | 柯春林 乔德亮 曾晓雄 |
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| 作者单位： | 1. 蚌埠学院生物与食品工程系,安徽蚌埠233030;南京农业大学食品科技学院,江苏南京210095
2. 南京农业大学食品科技学院,江苏南京,210095 |
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| 基金项目： | 蚌埠学院优秀人才基金，蚌埠学院博士科研启动基金 |
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| 摘 要： | 目的测定部分纯化的兽疫链球菌荚膜多糖（PCP）的抗氧化和免疫调节活性。方法以注射用环磷酰胺（CY）造成免疫抑制鼠模型。结果口服PCP诱导了免疫抑制鼠超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）的活性,提高了总抗氧化能力（TAOC）的水平。口服PCP后免疫抑制鼠的胸腺和脾脏指数明显增加,血清溶菌酶活性和迟发型超敏反应（DTH）引起的肿胀率也显著提高。结论 PCP对免疫抑制鼠具有免疫调节功能并改变CY诱导的氧化压力,是一种潜在的抗氧化剂和免疫调节剂。
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| 关 键 词： | 荚膜多糖 免疫抑制鼠 抗氧化 免疫调节 |
Antioxidant and immunomodulatory acitivity of the capsule polysaccharides from Streptococcus equi subsp.Zooepidemicus in immunosuppressed mice |
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| KE Chun-lin,QIAO De-liang,ZENG Xiao-xiong.Antioxidant and immunomodulatory acitivity of the capsule polysaccharides from Streptococcus equi subsp.Zooepidemicus in immunosuppressed mice[J].Chinese Journal of Microecology,2011,23(8):684-688. |
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| Authors: | KE Chun-lin QIAO De-liang ZENG Xiao-xiong |
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| Institution: | KE Chun-lin1,2,QIAO De-liang2,ZENG Xiao-xiong2(1.Department of Biotechnology and Food Engineering,Bengbu College,Bengbu 233030,China,2.College of Food Science and Technology,Nanjing Agricultural University,Nanjing 210095,China) |
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| Abstract: | Objective To evaluate the antioxidant and immunostimulatory activity of PCP in a cyclophosphamide(CY) induced immunosuppressed mice model.Method The partially purified capsule polysaccharides(PCP) were prepared from Streptococcus equi subsp.Zooepidemicus.Result Administration of PCP was able to overcome CY-induced immunosuppression and significantly raised the activity of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px) and total antioxidant capacity(TAOC) in immunosuppressed mice.And ... |
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| Keywords: | Capsule polysaccharides Immunosuppressed mice Antioxidant Immunomodulatory |
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