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| 纳米党参合剂调整肠道微生态失衡防治多器官功能障碍综合征的研究 | |
| 引用本文： | 王茉琳,闫冬梅,张淑红,杨景云.纳米党参合剂调整肠道微生态失衡防治多器官功能障碍综合征的研究[J].中国微生态学杂志,2011,23(10):874-876. |
| 作者姓名： | 王茉琳 闫冬梅 张淑红 杨景云 |
| 作者单位： | 1. 佳木斯大学基础医学院免疫教研室,黑龙江佳木斯,154007 2. 佳木斯大学基础医学院遗传教研室,黑龙江佳木斯,154007 3. 佳木斯大学微生态学研究中心,黑龙江佳木斯,154007 |
| 基金项目： | 国家重点基础研究发展计划(973计划)、(2007CB513008) |
| 摘 要： | 目的研究纳米党参合剂通过调整菌群失调,修复肠屏障功能,控制细菌、内毒素易位,对多器官功能障碍大鼠肠源性感染及内毒素血症(IETM)进行防治。方法采用肠缺血再灌注的方法制造多器官功能障碍综合征(MODS)模型,分别以纳米中药、常态中药对动物进行灌胃治疗。取肠内容物做无菌培养,内毒素、sIgA的测定,CD4+、CD8+T细胞计数。结果各治疗组通过扶植肠道有益菌、抑制有害菌的生长繁殖并促进其排泄,保护肠黏膜屏障,明显降低细菌易位,控制内毒素血症,改善相关免疫指标。结论党参合剂从调整微生态失调的角度来防治MODS取得较好效果,纳米中药效果更佳。 |
| 关 键 词： | 纳米中药 肠道菌群 细菌易位 多器官功能障碍 |
Nano-herbal Radix codonopsis mixture treat multiple organ dysfunction syndrome by adjusting intestinal tract dysbacteriosis |
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| WANG Mo-lin,YAN Dong-mei,ZHANG Shu-hong,YANG Jing-yun.Nano-herbal Radix codonopsis mixture treat multiple organ dysfunction syndrome by adjusting intestinal tract dysbacteriosis[J].Chinese Journal of Microecology,2011,23(10):874-876. | |
| Authors: | WANG Mo-lin YAN Dong-mei ZHANG Shu-hong YANG Jing-yun |
| Institution: | WANG Mo-lin1,YAN Dong-mei1,ZHANG Shu-hong2,YANG Jing-yun3 (1.Basic Medical College of Jiamusi University,Jiamusi 154007,China,2.Genetics Department,Basic Medical College of Jiamusi University,3.Microecology Research Center of Jiamusi University,China) |
| Abstract: | Objective To identify that Nano-herbal Radix codonopsis mixture would treat intestinal infection and endotoxemia of multiple organ dysfunction syndrome(MODS) by adjusting intestinal tract dysbacteriosis,repairing intestinal barrier function,and controlling bacteria and toxins translocation. Method MODS was induced by intestinal ischemia-reperfusion.The rats were treated with Nano-herbal and normal herbal radix codonopsis respectively.Bacteria quantity and location,plasma endotoxin,intestinal contents level ... |
| Keywords: | Nano-herb Intestinal bacteria Bacteria translocation Multiple organ dysfunction syndrome |
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