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| 纳米四君子汤对急性肝功能衰竭小鼠肠屏障功能的影响 | |
| 引用本文： | 鞠宝玲,徐艳敏,姚黎军,赵玉佳,海艳洁.纳米四君子汤对急性肝功能衰竭小鼠肠屏障功能的影响[J].中国微生态学杂志,2011,23(9):797-799. |
| 作者姓名： | 鞠宝玲 徐艳敏 姚黎军 赵玉佳 海艳洁 |
| 作者单位： | 1. 牡丹江医学院病原生物学教研室,黑龙江省高校肿瘤疾病防治重点实验室,黑龙江牡丹江 157011 2. 牡丹江红旗医院,黑龙江牡丹江,157011 3. 牡丹江医学院药学系,黑龙江牡丹江,157011 |
| 基金项目： | 黑龙江省教育厅资助项目 |
| 摘 要： | 目的探讨四君子汤常态制剂及纳米制剂对急性肝功能衰竭小鼠肠屏障功能的影响。方法 BALB/c小鼠经腹腔一次性注射D-GaIN/LPS,制备急性肝衰竭致肠屏障损伤模型,观察四君子汤常态制剂及其纳米制剂对肠道正常菌群,肠黏膜分泌型免疫球蛋白A（sIgA）含量,肠组织二胺氧化酶（DAO）活性及肝功能的影响。结果小鼠腹腔注射D-GaIN/LPS后,血清中ALT、AST活性显著提高（P〈0.01）;肠道内肠杆菌、肠球菌数量明显上升（P〈0.01）,乳酸杆菌、双歧杆菌数量明显下降（P〈0.05）;肠黏膜sIgA及肠组织DAO含量明显降低（P〈0.01）。治疗组上述指标均得到明显改善,与自然恢复组比较差异有统计学意义（P〈0.05,P〈0.01）;治疗组间比较四君子汤纳米制剂效果要好于常态制剂。结论急性肝功能衰竭时肠屏障明显受损,四君子汤常态制剂和纳米制剂均具有一定的保护作用,但纳米制剂效果优于常态制剂,且用药量小。 |
| 关 键 词： | 急性肝功能衰竭 肠黏膜屏障 纳米中药 |
Influence of nano Decoction of Four Mild Drugs on the intestinal barrier function in mice with acute liver failure |
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| JU Bao-ling,XU Yan-min,YAO Li-jun,ZHAO Yu-jia,HAI Yan-jie.Influence of nano Decoction of Four Mild Drugs on the intestinal barrier function in mice with acute liver failure[J].Chinese Journal of Microecology,2011,23(9):797-799. | |
| Authors: | JU Bao-ling XU Yan-min YAO Li-jun ZHAO Yu-jia HAI Yan-jie |
| Institution: | JU Bao-ling1,XU Yan-min2,YAO Li-jun2,ZHAO Yu-jia3,HAI Yan-jie2(1.Pathogenic Biology Department of Mudanjiang Medical College,Laboratory of Tumor Prevention and Treatment of Heilongjiang Province Universities,Mudanjiang 157011,China,2.Hongqi Hospital of Mudanjiang,3.Phamacy Department of Mudanjiang Medical College,China) |
| Abstract: | Objective To explore the influence of the conventional and nano preparation of Decoction of Four Mild Drug(DFMD) on the intestinal barrier function of the acute liver failure mice.Method Mice model of intestinal barrier disfunction resulted from acute liver failure were established by intraperitoneal injection of D-galactosamine(D-GalN) and endotoxin(LPS) and then the influence of the conventional DFMD and nano DFMD on the level of secretary IgA(sIgA) of intestinal mucosa,diamine oxidase(DAO) activity of in... |
| Keywords: | Acute liver failure Intestinal barrier Nano Chinese medicine |
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