Dimeric L-dopa derivatives as potential prodrugs |
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Authors: | Di Stefano A Mosciatti B Cingolani G M Giorgioni G Ricciutelli M Cacciatore I Sozio P Claudi F |
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Affiliation: | Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti, Italy. adistefano@unich.it |
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Abstract: | A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed. |
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