Acute hypoxemia does not increase the oxidative stress in resting and contracting muscle in humans |
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Authors: | Dousset Erick Steinberg Jean Guillaume Faucher Marion Jammes Yves |
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Affiliation: | Faculté des Sciences du Sport, Institut Fédératif de Recherches Jules Marey, Université de la Méditérranée, Marseille, France. |
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Abstract: | In healthy humans sustaining static handgrip at 60% of maximal voluntary contraction (MVC) until exhaustion, we measured the venous blood concentration of reduced ascorbic acid (RAA) and thiobarbituric acid reactive substances (TBARS), respectively, used as markers of the post-exercise oxidative stress and lipid peroxidation. Measurements were conducted in normoxemia, then during a 30-min period of hypoxemia (PaO 2 =56 mmHg) produced by inhalation of an hypoxic gas mixture. Compared to normoxemia, hypoxemia did not significantly modify the resting concentrations of TBARS and RAA, and did not affect the consumption of ascorbic acid after 60% MVC but suppressed the post-exercise TBARS increase. We conclude that acute hypoxemia does not modify the production of oxygen free radicals after strenuous static efforts and even seems to attenuate the lipid peroxidation. |
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Keywords: | Static Contraction Handgrip Oxidative Stress Hypoxemia |
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