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Comparative Genome Analysis of Prevotella ruminicola and Prevotella bryantii: Insights into Their Environmental Niche
Authors:Janaki Purushe  Derrick E. Fouts  Mark Morrison  Bryan A. White  Roderick I. Mackie  Pedro M. Coutinho  Bernard Henrissat  Karen E. Nelson
Affiliation:1. Department of Human Genomic Medicine, The J. Craig Venter Institute (JCVI), 9704 Medical Center Drive, Rockville, MD, 20850, USA
2. The MAPLE Research Initiative, Department of Animal Sciences, The Ohio State University, Columbus, OH, 43210, USA
5. CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD, Australia, 4069
3. Departments of Animal Sciences and Pathobiology, University of Illinois, 1207 W. Gregory Drive, Urbana, IL, 61801, USA
4. Architecture et Fonction des Macromolécules Biologiques, UMR6098, CNRS and Universités of Aix-Marseille I and II, 13288, Marseille, France
Abstract:The Prevotellas comprise a diverse group of bacteria that has received surprisingly limited attention at the whole genome-sequencing level. In this communication, we present the comparative analysis of the genomes of Prevotella ruminicola 23 (GenBank: CP002006) and Prevotella bryantii B14 (GenBank: ADWO00000000), two gastrointestinal isolates. Both P. ruminicola and P. bryantii have acquired an extensive repertoire of glycoside hydrolases that are targeted towards non-cellulosic polysaccharides, especially GH43 bifunctional enzymes. Our analysis demonstrates the diversity of this genus. The results from these analyses highlight their role in the gastrointestinal tract, and provide a template for additional work on genetic characterization of these species.
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