Increased expression of c-myc is associated with thymoma in rats infected with murine leukemia virus A8 |
| |
Authors: | Hirano Tomoko Watanabe Rihito Takase-Yoden Sayaka |
| |
Affiliation: | Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo 192-8577, Japan. |
| |
Abstract: | Infection of rats with Friend murine leukemia virus (Fr-MLV) clone A8 causes thymoma in all the animals within 7 weeks. The rapid induction of thymoma is associated with a unique enhancer structure in the U3 region of the A8-LTR. Our Southern blot analyses showed that the thymomas were oligo clonal. The A8-induced thymomas showed 3-to 11-fold overexpression of c-myc mRNA. These results suggest that provirus insertion into particular positions of the host genome is correlated with tumorigenesis after A8 infection and that up-regulation of c-myc plays an important role in the induction of thymoma. |
| |
Keywords: | thymoma friend murine leukemia virus c‐myc integration |
本文献已被 PubMed 等数据库收录! |