Protein stress and stress proteins: implications in aging and disease |
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Authors: | C S?ti Péter Csermely |
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Institution: | (1) Department of Medical Chemistry, Semmelweis University, PO Box 260, H-1444 Budapest 8, Hungary |
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Abstract: | Environmantal stress induces damage that activates an adaptive response in any organism. The cellular stress response is based
on the induction of cytoprotective proteins, the so called stress or heat shock proteins. The stress response as well as stress
proteins are ubiquitous, highly conserved mechanism, and genes, respectively, already present in prokaryotes. Chaperones protect
the proteome against conformational damage, promoting the function of protein networks. Protein damage takes place during
aging and in several degenerative diseases, and presents a threat to overload the cellular defense mechanisms. The preservation
of a robust stress response and protein disposal is indispensable for health and longevity. This review summarizes the present
knowledge of protein damage, turnover, and the stress response in aging and degenerative diseases. |
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Keywords: | Aging chaperone protein damage protein degradation stress protein |
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