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Synthesis and biological evaluation of a small library of nojirimycin-derived bicyclic iminosugars |
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| Authors: | Cipolla Laura Fernandes Marcos Reis Gregori Maria Airoldi Cristina Nicotra Francesco |
| Institution: | Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.za della Scienza 2, 20126 Milano, Italy. laura.cipolla@unimib.it |
| Abstract: | Novel nojirimycin-derived bicyclic structures, containing cyclic carbamate, urea and guanidine moieties have been synthesised starting from suitably protected alpha-C-vinylnojirimycin and alpha-C-allylnojirimycin, respectively, and their biological activity against different glycosidases and as antibacterial agents tested. |
| Keywords: | Iminosugars Nojirimycin Glycosidases Enzyme inhibitors Glucuronidase Antibacterial |
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