Novel P4 truncated tripeptidyl alpha-ketoamides as HCV protease inhibitors |
| |
| Authors: | Lamar Jason Victor Frantz Snyder Nancy Johnson Robert B Wang Q May Glass John I Chen Shu-Hui |
| |
| Affiliation: | Lilly Research Laboratory, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. |
| |
| Abstract: | We describe herein the synthesis and evaluation of two series of P-4 truncated tripeptidyl alpha-ketoamides as HCV serine protease inhibitors. The most promising compound disclosed in this communication 7b demonstrated enzyme binding affinity (K(i)) at 0.27 uM. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
