Phylogenetically widespread alternative splicing at unusual GYNGYN donors |
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| Authors: | Michael Hiller Klaus Huse Karol Szafranski Philip Rosenstiel Stefan Schreiber Rolf Backofen Matthias Platzer |
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| Institution: | (1) Institute of Computer Science, Chair for Bioinformatics, Albert-Ludwigs-University Freiburg, Georges-Koehler-Allee 106, 79110 Freiburg, Germany;(2) Genome Analysis, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstr. 11, 07745 Jena, Germany;(3) Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany;(4) Max Planck Institute for Molecular Genetics, Ihnestr. 63, 14195 Berlin, Germany |
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| Abstract: | Background Splice donor sites have a highly conserved GT or GC dinucleotide and an extended intronic consensus sequence GTRAGT that reflects
the sequence complementarity to the U1 snRNA. Here, we focus on unusual donor sites with the motif GYNGYN (Y stands for C
or T; N stands for A, C, G, or T). |
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