Action of barbiturates on activity of acetylcholinesterase from synaptosomal membranes |
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Authors: | Anna Pastuszko |
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Affiliation: | (1) Department of Neurochemistry, Medical Research Center, Polish Academy of Sciences, Dworkowa 3, 00-784 Warsaw, Poland |
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Abstract: | The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease theKm for acetylthiocholine, without changes inVmax. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity by about 4°C and increases activation energies. Nembutal and brietal do not change Arrhenius plot discontinuities, but they increase activation energies. These results suggest that barbiturates change lipid-protein interactions in synaptosomal membranes. |
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