Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population |
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Authors: | Tae-Ho Kim Jung Min Hong Hyun-Ju Kim Eui Kyun Park Shin-Yoon Kim |
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Institution: | 1. Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu, 700-412, Korea 2. Department of Medicine, Kyungpook National University School of Medicine, Daegu, 700-422, Korea 4. Department of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu, 700-412, Korea 3. Department of Orthopedic Surgery, Kyungpook National University School of Medicine, Daegu, 700-422, Korea
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Abstract: | Some studies have suggested that coagulation disorders may be implicated in osteonecrosis of the femoral head (ONFH). The
C677T polymorphism of the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene has been postulated to be a genetic risk factor for venous thromboembolism and osteonecrosis in Caucasians, but this
relationship has not been established in other populations. In this study, we conducted case-control analysis of whether MTHFR polymorphisms are associated with ONFH in Korean patients. Fifteen single nucleotide polymorphisms (SNPs) were selected and
genotyped in 443 ONFH patients and 273 control subjects using the TaqMan 5′ allelic discrimination assay. Comparison of ONFH
and control subjects using logistic regression models revealed no statistically significant differences in the frequencies
of the MTHFR polymorphisms and haplotypes. Further analysis stratified by etiology also showed no association. These results suggest that
MTHFR polymorphisms play no significant role in susceptibility to ONFH in the Korean population. |
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