Polymorphism in the Human Serotonin Transporter Gene in Endogenous Psychoses |
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| Authors: | Shcherbatykh T V Golimbet V E Orlova V A Kaleda V G Oleichik I V Abramova L M Tarantul V Z Rogaev E I |
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| Institution: | (1) Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, 115522, Russia;(2) Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia |
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| Abstract: | Associations of the VNTR-17 and 5-HTTLPR polymorphisms of the serotonin transporter gene with affective disorders, including depression, have been found. These polymorphisms were analyzed in two groups of Russian probands: patients with endogenous psychoses and control individuals without mental disorders (423 and 277 persons, respectively). No associations were found between VNTR-17 genotypes or alleles and the diseases. However, the frequency of10/10 (VNTR-17) homozygotes increased with age in both patients and healthy persons. The results of the analysis of the 5-HTTLPR polymorphism suggest an association of the short (s) allele of the 5-HTTLPR polymorphism with schizophrenia and schizoaffective psychoses, but not with affective disorders. |
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