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Influence of nerve fiber K+ depolarization and altered membrane protein conformation on the state of myelin
Authors:N N Rodionova  E Z Bibineyshvili  A R Brazhe  A I Yusipovich  G V Maksimov  A B Rubin
Institution:1. Biological Faculty, Moscow State University, Moscow, 119991, Russia
Abstract:Using Raman spectrometry and fluorescence microscopy, we studied the rearrangement of carotenoid molecules and membrane-bound Ca mb 2+ in myelinated nerve fibers after K+ depolarization, K+-channel blocking, and altering the membrane protein conformation. We observed a decrease in Ca mb 2+ and an increase of microviscosity in myelin after depolarization. Changes in Ca mb 2+ and microviscosity were registered after blocking the K+ channels and modifying proteins with PCMB. Our results suggest an interconnection between the condition of nerve fiber membrane proteins, Ca mb 2+ distribution, and myelin microviscosity.
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