|
|||||
|
|
Neuronal and muscular alterations caused by two wheat endosperm proteins,puroindoline-a and alpha1-purothionin,are due to ion pore formation |
|
| Authors: | Paola?Llanos Mauricio?Henriquez Jasmina?Minic Khalil?Elmorjani Didier?Marion Gloria?Riquelme Jordi?Molgó |
| Institution: | (1) Laboratoire de Neurobiologie Cellulaire et Moléculaire, UPR 9040, Institut Fédératif de Neurobiologie Alfred Fessard, CNRS, bât. 32–33, 91198 Gif sur Yvette Cedex, France;(2) Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia No. 1027, Casilla 70005, Santiago 6530499, Chile;(3) Laboratoire de Biochimie et Technologie des Protéines, INRA, B.P. 1627, 44316 Nantes Cedex 03, France |
| Abstract: | Using the patch-clamp technique it was found that the toxicity of the two wheat endosperm proteins puroindoline-a and alpha1-purothionin probably results from the dissipation of ion concentration gradients essential for the maintenance of cellular homeostasis.Abbreviations PIN-a
puroindoline-a
- PTH
alpha1-purothionin
Presented at the Biophysical Society Meeting on  Ion Channels—from structure to disease held in May 2003, Rennes, France |
| Keywords: | Giant liposomes Mouse neuromuscular junction Neuroblastoma cells Pore formation Wheat endosperm proteins |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |