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Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents |
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| Authors: | Lin Ronghui Connolly Peter J Lu Yanhua Chiu George Li Shengjian Yu Yang Huang Shenlin Li Xun Emanuel Stuart L Middleton Steven A Gruninger Robert H Adams Mary Fuentes-Pesquera Angel R Greenberger Lee M |
| Institution: | Johnson & Johnson Pharmaceutical Research & Development L.L.C., 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA. Ronghui.Lin@yahoo.com |
| Abstract: | A series of 3,5-disubstituted pyrazolo3,4-b]pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo3,4-b]pyridines and related compounds are reported. |
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