The isolation of cDNA clones for CD48 |
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Authors: | Hilary A. Vaughan Margaret M. Henning Damian F. J. Purcell Ian F. C. McKenzie Mauro S. Sandrin |
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Affiliation: | (1) Research Centre for Cancer and Transplantation, Department of Pathology, University of Melbourne, Parkville, 3052 Victoria, Australia |
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Abstract: | HuLy-m3 is an Mr 47 000 pan-leukocyte antigen detected by the monoclonal antibody (mAb) 5-4.8. This report describes the isolation and analysis of a cDNA clone encoding HuLy-m3. Serological analysis demonstrated that antibodies of the CD48 cluster also reacted with transfected cells expressing HuLy-m3. The DNA sequence of the clone suggests linkage to the cell membrane through a glycosyl phosphatidylinositol tail and this was verified experimentally. Sequence similarity with the human B-cell activation antigen Blast-1 was noted.The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number M 59904. |
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