|
|||||
|
|
Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors |
|
| Authors: | Matsufuji Tetsuyoshi Ikeda Mika Naito Asuka Hirouchi Masakazu Takakusa Hideo Kanda Shoichi Izumi Masanori Harada Jun Shinozuka Tsuyoshi |
| Affiliation: | Lead Discovery & Optimization Research Laboratories I, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo, Japan. |
| Abstract: | The discovery, optimization and structure-activity relationship of novel FATP1 inhibitors have been described. The detailed SAR studies of each moiety of the inhibitors combined with metabolite analysis led to the identification of the potent inhibitors 11p and 11q with improved blood stability. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |