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Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists |
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| Authors: | Dzierba Carolyn D Sielecki Thais M Arvanitis Argyrios G Galka Amy Johnson Tricia L Takvorian Amy G Rafalski Maria Kasireddy-Polam Padmaja Vig Shikha Dasgupta Bireshwar Zhang Ge Molski Thaddeus F Wong Harvey Zaczek Robert C Lodge Nicholas J Combs Andrew P Gilligan Paul J Trainor George L Bronson Joanne J Macor John E |
| Institution: | Neuroscience Discovery Chemistry, Research and Development, Bristol-Myers Squibb Co, Wallingford, CT 06492, United States. carolyn.dzierba@bms.com |
| Abstract: | Pyrido3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones were evaluated as corticotropin-releasing factor-1 receptor antagonists. The synthesis, SAR studies and pharmacokinetic evaluation of these analogs are described herein. |
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