Simple and stereoselective syntheses of nucleoside analogues with a benzo[c]furan glycone moiety. |
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| Authors: | D F Ewing N Fahmi G Mackenzie A Pranzo |
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| Affiliation: | Department of Chemistry, University of Hull, UK. |
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| Abstract: | A series of d4T analogues have been synthesised in which the 2',3'-didehydro-2',3'-dideoxyribose moiety is replaced by a benzo[c]furan core. A simple strategy has been developed to access a range of compounds for biological screening. In addition, a stereoselective approach has been achieved with view to permit more detailed studies. |
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