Gastric mucosal binding studies with enprostil: A potent anti-ulcer prostaglandin期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Gastric mucosal binding studies with enprostil: A potent anti-ulcer prostaglandin

Authors:	Sidney K. Woo A.Peter Roszkowski L.David Waterbury Gabriel L. Garay

Affiliation:	1. Graduate Program in Medical Sciences, Fluminense Federal University, Niterói, Brazil;2. Graduate Program in Cardiovascular Sciences, Fluminense Federal University, Niterói, Brazil;3. Graduate Program in Nutrition Sciences, Fluminense Federal University, Niterói, Brazil;4. Institute of Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil;5. Division of Nephrology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;6. Wolfson Wohl Translational Research Centre, ICS, University of Glasgow, Glasgow, Scotland;7. Division of Renal Medicine, Department of Clinical Science, Technology and Intervention, Karolinska Institute, Stockholm, Sweden

Abstract:	The potent antiulcer prostaglandin enprostil binds with high affinity to porcine gastic mucosal tissues. This binding is saturable, dissociable and displaceable by compounds with similar structures. Various characteristics of binding such as pH optimum and displacement potencies suggest that enprostil binds to mucosal PGE₂ sites. Structure-activity and gastric mucosal binding relationships were also examined.

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