Zetidoline, a novel neuroleptic, activates nigral dopaminergic neurons in rats |
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| Authors: | G Mereu B Fanni M Collu A Diena A Glasser |
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| Institution: | 1. Institutes of Biology, University of Cagliari, Italy;1. Pharmacology, University of Cagliari, Italy;7. Lepetit Research Laboratory, Milan, Italy |
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| Abstract: | Zetidoline (ZET), a rather selective dopamine (DA) D2-receptor blocker, was found to be equipotent to haloperidol and over 300 times as potent as sulpiride in activating the firing rate of substantia nigra dopaminergic neurons (SN-DA neurons) in unanesthetized rats. Moreover, like classic and atypical neuroleptics, ZET reversed and prevented apomorphine-induced inhibition of SN-DA neurons. |
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