| 对比剂动力学时间分辨成像及弥散加权成像技术活体动态监测兔VX2肌肉肿瘤生物学生长与血管生成 |
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| 引用本文： | 王悍,张贵祥,郑林丰,王夕富,李康安,沈晨.对比剂动力学时间分辨成像及弥散加权成像技术活体动态监测兔VX2肌肉肿瘤生物学生长与血管生成[J].现代生物医学进展,2010,10(5). |
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| 作者姓名： | 王悍 张贵祥 郑林丰 王夕富 李康安 沈晨 |
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| 作者单位： | 上海交通大学附属第一人民医院放射科,上海,200080 |
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| 基金项目： | 国家自然科学基金项目(30901730); 教育部博士点基金(20090073110072); 上海市卫生局青年科研项目(2008Y108); 上海交通大学医学院博士创新基金(BXJ0934) |
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| 摘 要： | 目的:应用对比剂动力学时间分辨成像(Time Resolved Imaging of Contrast Kinetics,TRICKS)技术增强磁共振血管成像(MRangiography,MRA)及弥散加权成像(Diffusion Weighted Imaging,DWI)技术活体动态监测兔VX2肌肉肿瘤生物学生长与血管生成,探讨肿瘤血管生成与肿瘤生长的关系。方法:30只新西兰白兔,每只均在右后腿肌肉内接种VX2肿瘤细胞1×107建立肿瘤模型。分别在肿瘤接种后第4、7、10、13、16天(每个时间点6只)分别进行T1WI、T2WI、DWI、TRICKS动态增强MRA及T1WI增强延迟扫描,活体监测兔VX2肌肉肿瘤血管生成,肿瘤标本HE及CD31免疫组化染色进行验证。两位医师双盲法分别测量不同生长点肿瘤的长、短径及体积,并与大体病理标本比较;测定TRICKS增强动态MRA所能显示肿瘤血管的最小直径及形态变化;观察ADC值变化与肿瘤生长的关系。结果(:1)ADC值随着肿瘤体积的长大而逐渐增大。(2)MRI活体测定肿瘤大小与病理大体标本所测算肿瘤体积的差异无显著性。(3)TRICKS增强MRA动态显示肿瘤血管的最小...
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| 关 键 词： | 肿瘤 血管生成 磁共振成像 血管造影 弥散加权成像 |
Dynamically Monitoring Tumor Growth and Angiogenesis in VX2 Muscle Tumor of Rabbits by Time Resolved Imaging of Contrast Kinetics and Diffusion Weighted Imaging Technique |
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| WANG Han,ZHANG Gui-xiang,ZHENG Lin-feng,WANG Xi-fu,LI Kang-an,SHEN Chen.Dynamically Monitoring Tumor Growth and Angiogenesis in VX2 Muscle Tumor of Rabbits by Time Resolved Imaging of Contrast Kinetics and Diffusion Weighted Imaging Technique[J].Progress in Modern Biomedicine,2010,10(5). |
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| Authors: | WANG Han ZHANG Gui-xiang ZHENG Lin-feng WANG Xi-fu LI Kang-an SHEN Chen |
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| Abstract: | Objective:To study the feasibility of dynamic monitoring tumor growth and angiogenesis by time resolved imaging of contrast kinetics (TRICKS) and diffusion weighted imaging (DWI) technique on a 3T MR system in vivo,and elucidate the relationship between tumor angiogenesis and tumor growth.Methods:Thirty New Zealand white rabbits were implanted VX2 tumors in the right thigh muscle,then the rabbits received T1WI,T2WI,DWI,TRICKS enhanced MR angiography (MRA)and T1WI enhanced delaying scanning on 3T MR at 4,7,1... |
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| Keywords: | Tumor Angiogenesis Magnet Resonance Imaging Angiography Diffusion Weighted Imaging |
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