Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide |
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Authors: | Kuil Joeri Buckle Tessa Yuan Hushan van den Berg Nynke S Oishi Shinya Fujii Nobutaka Josephson Lee van Leeuwen Fijs W B |
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Institution: | Division of Diagnostic Oncology, The Netherlands Cancer Institute , Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. |
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Abstract: | The antagonistic Ac-TZ14011 peptide, which binds to the chemokine receptor 4, has been labeled with a multifunctional single attachment point reagent that contains a DTPA chelate and a fluorescent dye with Cy5.5 spectral properties. Flow cytometry and confocal microscopy showed that the bimodal labeled peptide gave a specific receptor binding that is similar to monofunctionalized peptide derivatives. Therefore, the newly developed bimodal peptide derivative can be used in multimodal imaging applications. |
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