Two new lignans and anti-HBV constituents from Illicium henryi |
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| Authors: | Liu Ji-Feng Jiang Zhi-Yong Geng Chang-An Zhang Quan Shi Yao Ma Yun-Bao Zhang Xue-Mei Chen Ji-Jun |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.?R. China, (phone: +86‐871‐5223265;2. fax: +86‐871‐5223265);3. Graduate School of Chinese Academy of Sciences, Beijing 100039, P.?R. China;4. Hawley & Hazel Chemical (ZS) Co., Ltd, Zhongshan 528411, P.?R. China |
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| Abstract: | Two new lignans, dihydrodehydrodiconiferyl alcohol 9‐O‐β‐D ‐(3″‐O‐acetyl)‐xylopyranoside ( 1 ) and threo‐4,9,9′‐trihydroxy‐3,3′‐dimethoxy‐8‐O‐4′‐neolignan 7‐O‐α‐rhamnopyranoside ( 2 ) were isolated from Illicium henryi, together with ten known compounds, 3 – 12 . Their structures were elucidated by extensive spectroscopic analyses. The anti‐hepatitis B virus (anti‐HBV) activity of compounds 1 – 12 inhibiting HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line was evaluated. (−)‐Dihydrodehydrodiconiferyl alcohol ( 4 ) showed moderate inhibitory activity on both HBsAg and HBeAg secretion with IC50 values of 0.06 and 0.53 mM , respectively. |
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| Keywords: | Illicium henryi Hepatitis B virus (HBV) Lignans Antiviral activity |
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