Bovine Serum Albumin Binding and Drug Delivery Studies with PVA-Ferrofluid |
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Authors: | Suprabha Nayar Aparna Mir Aarti Ashok Avijit Guha Vikas Sharma |
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Affiliation: | National Metallurgical Laboratory, Jamshedpur 831007, India |
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Abstract: | This paper describes a single-step method for the biomimetic synthesis of stably suspended magnetite nanoparticles in poly(vinyl alcohol) termed ferrofluids. The challenge is to synthesize water based stable magnetic colloids with a control over the particle size and morphology for biomedical applications. The polymer possibly plays a dual role of a surfactant and a functionalizing agent. Transmission electron microscopy, infrared spectroscopy and vibrating sample magnetometry were used to investigate the properties of the synthesized ferrofluids. It has a strong affinity towards the tryptophan residues in bovine serum albumin protein as determined from the fluorescence emission studies. For in vivo applications this could indirectly mean a resistance to immune response and thus ensure long-term circulation. The ability of the synthesized ferrofluid to bind a che-motherapeutic drug ceftriaxone and its ionic release was observed. The polymer hydroxyl group allows drug-binding and the magnetic property allows targeting to specific sites. Magnetic hybrid fluids with combined advantages of magnetism and polymer open up new perspectives for applications. |
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Keywords: | biomimetic synthesis ferrofluids poly (vinyl alcohol) bovine serum albumin superparamagnetism |
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