Cis-trimethoxystilbene,exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines |
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| Authors: | Natá lia dos Santos Gonç alves,Tamires Maria Silva Pereira de Mello,Cá ssia Suemi Mizuno,Saqlain Haider,Raquel Alves dos Santos |
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| Affiliation: | 1.Universidade de Franca, Laboratório de Genética e Biologia Molecular, Franca, SP, Brazil.;2.University of New England, Westbrook College of Health Professions, School of Pharmacy, Department of Pharmaceutical and Social Administrative Sciences, Portland, ME, USA.;3.University of Mississippi, School of Pharmacy, National Center for Natural Products Research, MS, USA. |
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| Abstract: | Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis- and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested that the genotoxicity of cis- and trans-TMS is involved in the reduction of cellular proliferation of MCF-7 and MCF-10A cells, but notably, such antiproliferative effects are more pronounced for cis- than trans-TMS. |
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| Keywords: | Stilbenes genotoxic cell cycle arrest apoptosis |
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