替吉奥联合顺铂治疗晚期胃癌临床疗效研究

目的:研究替吉奥联合顺铂治疗晚期胃癌的疗效和安全性.方法:42例晚期胃腺癌患者随机分为观察组(21例)与对照组(21例)两组,观察组采用替吉奥联合顺铂,对照组采用卡培他滨联合顺铂.结果:两组患者疗效间差异无统计学意义(P＞0.05).两组的不良反应主要为骨髓抑制、消化道反应和乏力,观察组Ⅲ～Ⅳ度血小板减少发生率显著低于对照组(P＜0.05),Ⅲ～Ⅳ度手足综合征的发生率亦显著低于对照组(P＜0.05).结论:替吉奥联合顺铂治疗晚期胃癌疗效与卡培他滨联合顺铂相当,但其患者耐受性更好,值得临床进一步研究推广使用.

Curative Effect Analysis of S-1 Combined with Cisplatin in the Treatment of Advanced Gastric Cancer

Objective: To investigate the safety and efficacy of S-1 combined with cisplatin in the treatment for patients with advanced gastric cancer.Methods: Forty-two patients with advanced gastric cancer were randomly divided into two groups.Patients in observation group(n=21) received S-1 and cisplatin;Patients in control group(n=21) received capecitabine and cisplatin.Results: The efficacy of the two groups showed no statistically significant difference(P>0.05).The main untoward effects were myelosuppression,gastroenteric reaction and weakness.Observation group showed a lower rate of untoward effects than control group.Observation group also showed a lower rate of Ⅲ～Ⅳ thrombocytopenia(P<0.05) and hand-foot syndrome(P<0.05) than control group.Conclusions: The treatment of the two groups were evidently effective,with observation group having better tolerance.The regimen could be clinically recommended.