非酒精性脂肪性肝病的发病机制及治疗进展

近年来,随着人们生活水平的提高,脂肪性肝病的发病率明显上升,且患病年龄趋于低龄化,已经成为严重危害我国人民健康的常见疾病,我国非酒精性脂肪性肝病的发病率明显高于酒精性脂肪性肝病。本文主要对NAFLD的发病机制及相关治疗进展做简要的综述。NAFLD的发病机制与胰岛素抵抗、氧化应激、代谢综合征、脂肪细胞因子的作用、内质网应激、及铁超载等多种因素有关。NAFLD的治疗可以从防治原发病或相关危险因素、基础治疗(行为或生活方式干预;调整饮食;运动疗法)、药物治疗以及手术治疗等方面进行。了解国际上NAFLD的发病机制以及相关治疗进展,对遏制非酒精性脂肪性肝病的发生、发展趋势有着十分重要的意义。

The Pathogenesis and Therapy in Current Progression of Nonalcoholic Fatty Liver Disease

With the improvement of living standards in recent years,the incidence of fatty liver increased significantly,and tend to suffer from a younger age.It has become a common disease with serious threat to the health of our people.China’s non-alcoholic fatty liver disease was significantly higher than the alcoholic fatty liver.This article is a summary focuses on the pathogenesis of NAFLD and related treatment.The pathogenesis of NAFLD is related to Insulin Resistance,Oxidative Stress,Metabolic Syndrome,the effect of fatty cytokine,Endoplasmic Reticulum Stress and Iron Overloading.Treatment of NAFLD include control the primary disease or related risk factors,basic treatment(behavioral or lifestyle interventions;to adjust your diet;exercise therapy),drug therapy and surgical treatment and other aspects.It is very important to curb the development trend of fatty liver through the understanding of international NAFLD pathogenesis and treatment progress.