PEDF 在类风湿关节炎滑膜组织中的表达及临床意义

目的:研究类风湿关节炎患者滑膜组织中色素上皮衍生因子(Piment epithelial-derived factor,PEDF)的表达情况。方法:采用免疫组化法,检测30例类风湿关节炎活动期膝关节滑膜组织中PEDF蛋白表达,以16例退行性关节炎患者、16例正常人及该30例患者治疗后(稳定期)关节滑膜组织中PEDF蛋白作对照,进行对比分析。结果:PEDF在类风湿关节炎患者明显低于正常人、退行性关节炎患者滑膜组织中的表达,在活动期滑膜组织中的表达明显低于稳定期,组间比较,差异均有统计学意义(P均<0.05)。结论:PEDF与类风湿关节炎的疾病过程密切相关,针对色素上皮衍生因子的靶点治疗有望成为类风湿关节炎治疗的新的方向及策略。

Expression and Clinical Significance of PEDF in RheumatoidArthritis Synovium

Objective: To study the expression of piment epithelial-derived factor(PEDF) in human rheumatoid arthritis synovium.Methods: Expression of PEDF protein was detected by immunohistochemistry in 30 cases of active rheumatoid arthritis synovium,that after treatment,16 patients with retrograde arthritis and 16 normal subjects as controls.Results: In the experimental group,the PEDF expression was significantly lower than in normal subjects and patients with retrograde arthritis.In the experimental group,PEDF expression was also significantly lower than in the patients after treatment.There was statistical difference between experimental group and control groups(P<0.05).Conclusion: PEDF expression is closely related to the progression of rheumatoid arthritis.It’s a new direction to be expected that piment epithelial-derived factor may be the target treatment of rheumatoid arthritis treatment.