带状疱疹后遗神经痛的动物模型及病理机制研究

带状疱疹后遗神经痛(postherpetic neuralgia,PHN)是带状疱疹最常见的并发症,其发生率随年龄的增加而增加,并且严重影响患者的生活质量。目前PHN的治疗多采用复合用药,但效果不佳。阻碍其治疗发展的关键是对PHN的发病机制不甚清楚,究其根本原因是缺乏与临床符合的动物模型。目的:综述带状疱疹病毒感染模型的改良和进展,使PHN的病理机制得到进一步揭示。内容:介绍与PHN相关的水痘-带状疱疹病毒潜伏感染模型、体外模型及慢性感染模型,综述与PHN发生发展有关的潜伏机制、与其他神经病理性痛相似的机制及近年来较为关注的中枢与外周损伤机制。趋向:进一步研究与人类水痘带状疱疹病毒感染更为相似的动物模型,并随其改良和进展,使发生PHN的机制得到进一步的阐释。

The Animal Model and Pathogenesis Research of Postherpetic Neuralgia

PHN(Postherpetic neuralgia,PHN) is the most common complication of shingles zoster,the incidence of which is increased with age,which affect the quality of patient seriously.At the present,the PHN is often treated with complex medication,but the affect is not obvious.However,the development of therapies to PHN has been hampered by the unclear of the pathogenesis of PHN,and further more by the lock of animal models which is coincident with clinical.This review introduced the improvement and further research of the animal model infected by VZV(varicella zoster virus,VZV),the pathological of PHN will be further revealed.Content: The animal model of latent infection,in vitro infection and chronic infection associated with PHN are described,in additional,the latent mechanism,the mechanism similar with the other neuropathic pain and the damage of centrum and periphery which is paid more attention by the research are also introduced in detail.Trend: With the further research of animal model which is more coincident with clinical,and the pathological mechanism of PHN will be further revealed with progressing of animal model of PHN.