Src 在胃癌中的作用

Src是非受体型酪氨酸激酶家族成员之一,通过广泛的信号转导通路参与HP感染、胃癌细胞粘附、受体调节、增殖和血管形成等。近年来研究表明,Src在胃癌组织中异常表达或活性增高,与胃癌的发生发展密切相关。因此,研究Src和胃癌的关系有着重要意义。目前,针对Src的靶向抑制剂已经进入临床试验。大量研究发现,Src抑制剂包括Dasatinib、AZD0530、Sunitinib等对胃癌有抑制作用,这将为胃癌的治疗开辟新的治疗途径。

The Role of Src in Gastric Cancer

The Src protein is identified as a member of the largest family of nonreceptor protein tyrosine kinases and has been strongly linked to its ability to responsible for a diverse array of key signal transduction pathways in regulating Helicobacter pylori(H.pylori) infection,cell adhesion,Receptor-Mediated,proliferation and angiogenesis of the gastric cancer.In recent years,researchers have revealed that Src is excessive expressed or activated in gastric cancer cell lines and tissue,which may be intimately correlated with the develop-ment and progression of the gastric cancer by facilitating the action of other signaling proteins.This indicates that Src may represent a po-tentially promising therapeutic target for patients with gastric cancer.So far,a number of inhibitors of Src kinase have been begun to move in clinical trials.Studies suggest that the Src inhibitors,including Dasatinib,AZD0530,Sunitinib could block Src activation and in-hibit these pathways,resulting in antitumor activity of gastric cancer cell lines.The Src inhibitors may open a new pathway for the therapy of gastric cancer in the future.