FGF-2 在细胞凋亡中的作用机制

成纤维细胞生长因子2(fibroblast growth factor 2,FGF-2)具有多种细胞生物学功能。FGF-2在肿瘤组织中呈高水平表达状态,且可抑制多种化疗药物的促凋亡作用,从而曾为肿瘤细胞存活的重要刺激因素。但也有研究表明FGF-2可诱导部分细胞的分化和凋亡。鉴于FGF-2在肿瘤的发生发展中发挥的重要作用,FGF-2与细胞凋亡的关系及其相应的调节机制成为有待于深入研究和迫切需要解决的问题。本文主要阐述在细胞凋亡通路中,FGF-2关键分子的作用机制及其最新研究进展。

The Role of FGF-2 in the Mechanism of Apoptosis

The last growth factor 2(FGF-2) has a variety of cell biological functions.In a number of tumor cells,the expression of FGF-2 is in high level,and FGF-2 can inhibit many pro-apoptotic effects of chemotherapy drugs,so that it is considered as a powerful stimulus of tumor cell survival.However,in some cell lines,FGF-2 can induce cell differentiation and apoptosis.According to the important role of FGF-2 in tumor development,the relationship between FGF-2 and cell apoptosis and its corresponding mechanism is to be in-depth study and urgent need to be solved.This review focuses on the role of key intermediary molecular of FGF-2 in apoptotic pathway and its recent progress.