妊娠期糖尿病孕妇血清脂质运载蛋白-2 水平变化及临床意义初探

目的:了解妊娠期糖尿病(GDM)孕妇血清脂质运载蛋白-2(LCN-2)水平的变化及临床意义,探讨LCN-2的永平变化是否与炎症反应相关.方法:测定30例GDM孕妇及30例正常孕晚期孕妇血清LCN-2水平、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(Fins)水平,计算胰岛素抵抗指数,检测白细胞计数(WBC)、中性粒细胞百分比(N)、及血清C反应蛋白(CRP)水平,并对两组结果进行统计对比分析.结果:(1)GDM组孕妇血清LCN-2水平为(70.69±6.85 )ng/mL,高于正常孕妇血清LCN-2水平(67.02±6.58)ng/mL,差异有统计学意义(P＜0.05).(2)GDM组孕妇FPG、HbA1c、Fins、HOMA-IR水平分别为(5.35±0.57)mmol/L、(5.66±0.60)％、(9.38± 1.32)mIU/L、(2.24±0.45)],明显高于正常孕妇血清水平(5.00±0.26)mmol/L.、(4.72± 0.51)％,(8.26±0.76)mIU/L、(1.83±0.23)],差异有统计学意义(P＜0.01).(3)GDM组孕妇血液WBC、N水平分别为(8.77±1.75)X 109/L、(72.07± 3.91)％,正常孕妇血清水平为(8.49± 1.26)x 109/L、(73.18±3.87)％,差异无统计学意义(P＞0.05).GDM组孕妇CRP水平为(5.21±0.91)g/L,正常孕妇血清水平CRP为(3.71±1.27)g/L,差异有统计学意义(P＜0.05).结论:GDM孕妇血清LCN-2水平升高,可能参与了GDM的病理过程,但血清LCN-2水平与临床常用的炎症反应标志物并不相关.

Change of Serum Lipocalin-2 Level in Pregnant Women with Gestational Diabetes Mellitus and its Clinical Significance

Objective: To explore change of serum lipocalin-2(LCN-2) level in pregnant women with gestational diabetes mellitus(GDM) and its potential clinical significance,as well as the association between LCN-2 level and inflammation.Methods: The levels of serum LCN-2,fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),Fasting insulin level(Fins),homeostasis model assess-ment ratio(HOMA-IR),leucocyte count,neutrophil percentage and C-reaction protein were tested in 30 GDM women and 30 normal controls.Results:(1)The level of serum LCN-2 in GDM group(70.69±6.85 ng/mL) was significantly higher than that in controls(67.02±6.58 ng/mL)(P<0.05).(2)The levels of FPG,HbA1C,Fins,HOMA-IR in the GDM group (5.35±0.57) mmol/L;(5.66±0.60)%;(9.38±1.32) mIU/L;(2.24±0.45)] were significantly higher than those in controls(5.00±0.26) mmol/L;(4.72±0.51)%;(8.26±0.76) mIU/L;(1.83±0.23)](P<0.01).(3)The leucocyte count and the neutrophil percentage between these two groups were not significantly different(8.77±1.75)×109/L vs(72.07±3.91)%;(8.49±1.26)×109/L vs(73.18±3.87)%](P>0.05).The CRP level in GDM group(5.21±0.91 g/L) was significantly higher than that in controls(3.71±1.27 g/L)(P<0.05).Conclusions: The higher level of LCN-2 indi-cates its potential role in the pathomechanism of GDM and this hypothesis warrants further research,since our results didn’t find associa-tion between LCN-2 level and inflammatory marker clinically commonly used.