GABABR 异二聚体和GB1-GB1 同二聚体中的GB1 亚基的作用

GABABR属于C族G蛋白偶联受体,是中枢神经细胞重要的抑制性神经递质受体.在体内GABABR由GB1和GB2两个基因编码,1998年以来研究者证实GABABR是由GB1和GB2形成的异二聚体,但近年来的研究表明,GB1也可以单独形成GB1 -GB1同二聚体并在体内行使功能.本文系统介绍了GB1亚基的分类,在GB2存在或不存在时的表达,以及在GABABR异二聚体和GB1-GB1同二聚体激活过程中所扮演的角色和生理功能；同时也展望了这些研究成果对于基础研究和药学研究的意义.

The Role of GB1 Subunit in GABABR Heterodimer and GB1-GB1 Homodimer

GABA B R belongs to the Class C G protein-coupled receptor,and it is important inhibitory neurotransmitter receptors in central nervous system.GABA B R is encoding by two genes,GB1 and GB2,and researchers have confirmed that GABA B R is heterodimer formed by GB1 and GB2 since 1998,but recent studies have shown that GB1 could form GB1-GB1 homodimer in the absence of GB2 and exercise functions in vivo.In present systematically review the different splice variants of GB1,and its expression in the presence or absence of GB2,and its role in the activation process of GABA B R heterodimer and GB1-GB1 homodimer as well as its physiologic effect in vivo;and also prospect the significance of the above studies in basic research and pharmacology.