扩张型心肌病患者恶性室性心律失常与心率变异性关系分析

目的:了解扩张型心肌病患者恶性心律失常(MVA)与心率变异性(heart rate variability,HRV)的关系,探讨扩心病患者体内自主神经变化的临床意义。方法:选择扩心病患者48例作为研究对象,同时按照年龄配对,取48例正常者作为对照组,对其行24小时动态心电图检查,依据其是否出现恶性心律失常分为恶性室性心律失常(MVA+)组及单纯扩张型心肌病(MVA-)组,分析组间HRV的差异。结果:与对照组比较,单纯扩张型心肌病(MVA-)组HRV时域指标(SDNN、SDANN、RMSSD)均有降低(P<0.05)L与(MVA-)组相比,恶性室性心律失常(MVA+)组HRV相关指标进一步降低(P<0.05)。结论:自主神经功能异常是扩张型心肌病患者恶性心律失常的重要危险因子,可能可以用HRV预测其发生恶性心律失常危险性。

Analysis of the Relation between HRV and Malignant Ventricular Arrhythmia in Patient with Dilated Cardiomyopathy

Objective: To analyze the relation between Heart Rate Variability(HRV) and malignant ventricular arrhythmia(MVA) in patient with dilated cardiomyopathy(DCM),and to provide clinic basis for predicting the risk of death.Methods: We divide the 48 patients with dilated cardiomyopathy into 2 groups according to MVA,we also collect 48 normal people as control.They are MVA(+) group,MVA(-) group and normal control group.We analyze the difference of HRV indexes such as SDNN,SDANN and RMSSD among the 3 groups.Results: The indexes of SDNN,SDANN and RMSSD in MVA(+) group are lower than those in MVA(-) group,and the indexes of HRV in MVA(-) group is lower than normal group using ANOVA.Conclusions: MVA is closely related to the decrease of HRV.HRV might be used to predict the incidence of MVA and sudden death in patient with DCM.