CD4+CD25+ 调节性T 细胞与冠状动脉粥样硬化病变的研究进展

CD4+CD25+调节性T细胞是一个具有独特免疫调节功能的T细胞亚群,人体主要通过CD4+CD25+调节性T细胞以免疫负向调节的方式来抑制自身反应性T细胞的作用,减少免疫性疾病的发生,从而维持机体内环境的稳定,维持免疫耐受。CD4+CD25+Treg已被证实其与肿瘤、感染、自身免疫病、移植免疫等多种疾病的发生、发展及转归均相关。随着社会的进步和人民生活水平的提高冠状动脉粥样硬化性病变作为一种慢性病变,其发病率越来越高,已经成为严重危害人类健康的常见病,近年来越来越多的证据表明炎症及免疫反应机制在冠状动脉粥样硬化性心脏病的发生、发展及预后过程中具有重要的作用。而CD4+CD25+调节性T细胞在冠状动脉粥样硬化性病变中所起的作用也受到越来越多的关注。本文就CD4+CD25+调节性T细胞与冠状动脉粥样硬化病变之间的关联做一综述。

CD4+CD25+Regulatory T cells and Coronary heart disease

CD4 + CD25 + regulatory T cells is a unique immune regulatory function of T cell subsets,in human beings to inhibit the function of autoimmune T cells by negatively regulating the autoreactive T cells in order to maintain a stable environment for the body,and maintain immune tolerance.CD4 + CD25 + Treg has been confirmed with the development and outcome of tumor,infection,autoimmune disease,transplantation and other immune diseases.Along with social progress and people’s living standards improve coronary atherosclerosis as a chronic degenerative disease,and its increasing incidence,has become a serious common disease hazard to human health.In recent years more and more evidence prove that the mechanisms of inflammation and immune response to the coronary atherosclerotic heart disease,development and prognosis of the process has an important role.The role of CD4+ CD25+ regulatory T cells played in coronary atherosclerotic lesions has been pay more and more attention.In this paper,we give a review of association between CD4 + CD25 + regulatory T cells and coronary atherosclerosis.