陀螺旋转式立体定向放射治疗联合NP 方案治疗局部晚期非小细胞肺癌 的临床疗效观察

目的:观察陀螺旋转式立体定向放射治疗系统(陀螺刀)联合长春瑞滨、顺铂(NP)方案治疗局部晚期非小细胞肺癌(NSCLC)的临床疗效观察及毒副反应。方法:94例局部晚期NSCLC患者,先给予陀螺刀治疗,单次治疗剂量3.2-5.0 Gy,等剂量曲线50%-70%,计划靶体积(PTV)覆盖95%以上,总剂量35-50 Gy,治疗后进行NP方案化疗4-6个周期。与同期144例单纯陀螺刀治疗局部晚期NSCLC患者治疗结果相比较。结果:联合治疗的94例患者,近期有效率为86.17%(81/94),6、12和24个月生存率分别为86.17%(81/94)、60.64%(57/94)和36.17%(34/94),毒性反应较轻。同期单纯陀螺刀治疗患者,近期有效率为88.19%(127/144),6、12和24个月生存率分别为87.50%(126/144)、44.44%(64/144)和23.68%(33/144)。结论:陀螺刀联合NP方案是一种对局部晚期NSCLC比较有效的治疗方法,毒副反应较轻。

Gyro Rotary Stereotactic Radiotherapy Combined NP Treatment Scheme Locally Advanced Non-small cell lung cancer Clinical Curative Effects

Objective: Observe gyro rotary stereotactic radiotherapy(gamma-SRT) joint changchun Rachel sedimentation and cisplatin(NP) treatment scheme locally advanced non-small cell lung cancer(NSCLC) the clinical curative effect of the observation and adverse reaction.Methods: 94 cases of patients with locally advanced NSCLC,first give gamma-irradiation SRT treatment,a single treatment dose 3.2-5.0 Gy,etc dose curve 50%-70%,and plans to target volume(PTV) covers more than 95%,total doses 35 to 50 Gy,treatment after 4-6 cycles of chemotherapy NP scheme.Compared with the 144 cases of pure gamma-irradiation SRT treatment for patients with lo-cally advanced NSCLC compared treatment results.Result: Combination therapy of 94 patients,recent effective rate was 86.17%(81/94),6,12 and 24 months survival rates were 86.17%(81/94),60.64%(57/94) and 36.17%(34/94),toxic reaction is lighter.Only the same pe-riod gamma-irradiation SRT treat the patient,recent effective rate was 88.19%(127/144),6,12 and 24 months survival rates were 87.50%(126/144),44.44%(64/144) and 23.68%(33/144).Conclusion: Gamma-irradiation SRT joint NP scheme is a local advanced-stage NSCLC does more effective treatments,adverse reaction is lighter.