NSE、CEA 和CYFRA21-1 测定对胸腔积液的诊断价值

目的:探讨神经元烯醇化酶(NSE)、癌胚抗原(CEA)和细胞角蛋白19(CYFRA21-1)测定对胸腔积液的诊断价值。方法:选择我院2009年4月～2011年9月收治的胸腔积液患者89例作为研究对象,按照胸腔积液性质分为两组,良性组47例,恶性组42例,对两组的NSE、CEA和CYFRA21-1测定结果进行比较分析。结果:恶性组患者血清和胸腔积液中NSE、CEA和CYFRA21-1水平均明显高于良性组,组间差异有统计学意义(P<0.05);NSE、CEA和CYFRA21-1联合检测对恶性胸腔积液的敏感性均明显高于单独NSE、CEA和CYFRA21-1检测,差异有统计学意义(P<0.05)。结论:NSE、CEA和CYFRA21-1测定对胸腔积液具有临床诊断价值,且三者联合检测能够明显提高诊断敏感性。

Diagnostic Values of NSE, CEA and CYFRA21-1 in Pleural Effusion

Objective: To investigate the diagnostic value of NSE,CEA and CYFRA21-1 determination of pleural effusion.Methods: From April 2009 to September 2011 in our hospital,87 patients of pleural effusion were selected as the study object,they were divided into two groups according to the nature of pleural effusion,47 cases of benign group and 42 cases of malignant group,the determination results of two groups were compared and analyzed.Results: The NSE,CEA and CYFRA21-1 in serum and pleural effusion of benign group were significantly higher than the malignant group,the differences were statistically significant between two groups(P<0.05);the sensitivity of NSE,CEA and CYFRA21-1 combined detection of malignant pleural effusion were significantly higher than NSE,CEA or CYFRA21-1 alone detection,and the difference was statistically significant between two groups(P<0.05).Conclusions: NSE,CEA and CYFRA21-1 determination of pleural effusion has diagnostic value,NSE,CEA and CYFRA21-1 combined detection can significantly improve the diagnostic sensitivity.