| 内皮祖细胞生物学特性及其进展 |
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| 引用本文： | 龚婷,贾素洁 张毕奎. 内皮祖细胞生物学特性及其进展[J]. 现代生物医学进展, 2012, 12(21): 4193-4196 |
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| 作者姓名： | 龚婷 贾素洁 张毕奎 |
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| 作者单位： | 1. 中南大学湘雅三医院药剂科 湖南长沙410013;中南大学药学院 湖南长沙410013
2. 中南大学湘雅三医院药剂科 湖南长沙410013 |
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| 基金项目： | 国家自然科学基金项目(30900621) |
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| 摘 要： | 内皮祖细胞(Endothelial Progenitor Cells,EPCs)是血管内皮细胞的前体细胞,即能分化为成熟血管内皮细胞的祖细胞。随着对EPCs功能和影响其分化、生存、归巢和组织分布因素的了解,EPCs作为临床诊断、预后判断和治疗方法将有广阔的前景。本文就EPCs的的来源,EPCs的分离、培养、鉴定,EPCs的表面标志,EPCs的动员、分化和归巢等生物学特性及其进展展开综述。
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| 关 键 词： | 内皮祖细胞 血管内皮生长因子 细胞动员 细胞分化 细胞归巢 |
Biological Characteristics of Endothelial Progenitor Cells and ItsAdvancement |
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| GONG Ting,JIA Su-jie,ZHANG Bi-kui. Biological Characteristics of Endothelial Progenitor Cells and ItsAdvancement[J]. Progress in Modern Biomedicine, 2012, 12(21): 4193-4196 |
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| Authors: | GONG Ting JIA Su-jie ZHANG Bi-kui |
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| Affiliation: | 1,2△(1 Dept.of Pharmacy,Third Xiangya Hospital of Central South University,Changsha,410013,China; 2 School of Pharmaceutical Sciences,Central South University,Changsha,410013,China) |
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| Abstract: | Endothelial progenitor cells(EPCs) are precursors of endothelial cells,which are able to differentiate into mature endothelial cells.Studies are needed to increase more detailed understanding on the mechanisms of EPCs differentiation,survival,homing and distribution of the tissue.The human EPCs has potential to be used as diagnostic and prognostic or therapeutic tools in the future.This paper reviewed the biological characteristics and its advancement of EPCs,which including separation,culture and iden-tification,surface marker,mobilization,differentiation and homing. |
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| Keywords: | Endothelial progenitor cells(EPCs) Vein endothelial growth factors receptor(VEGF) Cell mobilization Cell differenti-ation Cell homing |
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