几种天然产物对高尿酸血症大鼠血清尿酸水平的影响初探

目的:探讨几种天然产物对高尿酸血症大鼠血清尿酸水平及尿酸排泄的影响.方法:对wistar大鼠灌胃氧嗪酸钾和酵母膏,制作高尿酸血症大鼠动物模型.灌胃给药褐藻糖胶、柠檬酸钾和东哥阿里提取物,2周后采血并进行代谢实验,检测血清尿酸、尿素氮,24小时尿液体积、pH值、尿酸浓度及总量,分析三种活性物质对机体尿酸水平、尿酸排泄、肾脏功能的影响.结果:三种物质均可显著降低高尿酸血症模型大鼠的血清尿酸水平,其中东哥阿里提取物组的24小时排泄尿酸总量较模型组显著降低,褐藻糖胶对实验大鼠的血清尿素氮水平升高有抑制作用.结论:三种活性物质对高尿酸血症大鼠血清尿酸浓度有降低作用,其中褐藻糖胶对肾脏功能有保护作用,从而保证尿酸的顺利排泄,而东哥阿里在降低血尿酸水平的同时,24小时尿液中排泄的尿酸总量也显著低于模型对照组,其机制可能与抑制尿酸生成有关.

Effects of Several Natural Extracts on Uric Acid in Serum of Hyperuricemic Rats

Objective:To investigate the effects of several natural products on the serum uric acid concentration and uric acid excretion of hyperuricemic rats.Methods:Administrating potassium hydrochloride and yeast extract to produce animal hyperuricemic models in rats.Oral administration of fucoidan,potassium citrate,Tongkat Ali extract for 2 weeks,after the metabolic experiments and collecting the serum,the serum uric acid concentration,urea nitrogen level,24-hour urine volume,pH,uric acid concentration and total amount were determined.Results:All the three products could significantly reduce the serum uric acid in hyperuricemic rats.The total 24-hour excretion of uric acid of Tongkat Ali group rats was significantly lower than the model group,while the fucoidan inhibited the higher serum urea nitrogen levels.Conclusions:These three products decreased serum uric acid concentration.Fucoidan has a protective effect on renal function,which ensure the excretion of uric acid.And while the Tongkat Ali reducing the serum uric acid concentration in rats,24-hour urine excretion of uric acid volume was significantly decreased compared with the model group,and the mechanism may be related to the inhibition of uric acid generation.