前体蛋白转化酶家族的重要成员之一：弗林蛋白酶

弗林蛋白酶(Furin)是前体蛋白转化酶家族的重要成员之一,广泛存在于各种组织和细胞系中。Furin经过两次自剪切去掉前肽后具有生理活性,能够识别特定的氨基酸序列并在TGN中对多种前体蛋白进行加工。Furin的作用底物不仅包括神经肽和肽类激素,还包括许多生长因子、受体、血浆蛋白酶、基质金属蛋白酶及细菌外毒素等,具有重要的生物学功能。

An Important Member of the Family of Proprotein Convertases: Furin

Furin is a key member of the family of proprotein convertases,which is expressed in all tissues and cell lines.It will gain its bioactivity after two self-cleavages and activate many other proproteins into their biologically active forms in the trans-Golgi net-work,because it can identify the specific amino acid sequence.Furin possesses important biological functions as it is capable of cleaving precursors of a wide variety of proteins,not only neuropeptides and peptide hormones,but also many growth factors,receptors,plasma proteases,matrix metalloproteinases and bacterial exotoxins.