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| 糖尿病大鼠内嗅皮层神经元放电与场电位相干性研究 | |
| 引用本文： | 谢康宁,申广浩,田越,刘娟,闫一力,罗二平,许全盛.糖尿病大鼠内嗅皮层神经元放电与场电位相干性研究[J].现代生物医学进展,2012,12(16):3071-3073. |
| 作者姓名： | 谢康宁 申广浩 田越 刘娟 闫一力 罗二平 许全盛 |
| 作者单位： | 1. 第四军医大学 陕西西安710032 2. 第四军医大学,西京医院 陕西西安,710032 3. 燕山大学电气工程学院 河北秦皇岛006004 |
| 基金项目： | 国家自然科学基金(31000491) |
| 摘 要： | 目的:通过分析神经元放电与场电位的相干性,探讨内嗅皮层神经元放电与场电位的关系。方法:10只成年大鼠随机分2组,一组糖尿病建模,另一组作为对照,记录对照组和糖尿病组大鼠的内嗅皮层神经元放电锋电位和场电位,利用点过程谱分析方法对神经元放电与场电位相干性进行分析对比。结果:糖尿病大鼠麻醉神经元放电与场电位的相干性明显低于对照组(P<0.01)。结论:糖尿病大鼠内嗅皮层神经元功能受到损害。 |
| 关 键 词： | 糖尿病 相干 内嗅皮层 |
The Spike-field Coherence Analysis of Neural Signals From Entorhinal Cortex of Diabetic Rats |
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| XIE Kang-ning,SHEN Guang-hao,TIAN Yue,LIU Juan,YAN Yi-li,LUO Er-ping,XU Quan-shen.The Spike-field Coherence Analysis of Neural Signals From Entorhinal Cortex of Diabetic Rats[J].Progress in Modern Biomedicine,2012,12(16):3071-3073. | |
| Authors: | XIE Kang-ning SHEN Guang-hao TIAN Yue LIU Juan YAN Yi-li LUO Er-ping XU Quan-shen |
| Institution: | XIE Kang-ning1,SHEN Guang-hao1,TIAN Yue2,LIU Juan1,YAN Yi-li1,LUO Er-ping1,XU Quan-shen3(1 School of Biomedical Engineering,The Fourth Military Medical University,Xi’an 710032,China; 2 Xijing Hospital,Xi’an,The Fourth Military Medical University,Xi’an Shaanxi 710032,China; 3 Yanshan University,Qinhuangdao,066004,China) |
| Abstract: | Objective: To study neural signal coordination of diabetic rats by analyzing the spike-field coherence(SFC).Methods: The 10 adult rats were divided randomly into two groups: 5 in control group and 5 in diabetic group.Local field potentials and neuronal spikes were recorded from the entorhinal cortex.Using the spectrum analysis method of point process,the SFC was conducted for signals from entorhinal cortex in both groups.Results: The SFC was significantly lower in diabetic group than in control group(P<0.01).Conclusion: The results suggest the impairment of neural functioning for diabetic rats. |
| Keywords: | Diabetes Coherence Entorhinal cortex |
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