鼻咽癌的CT 显像与VEGF 和p53 蛋白表达的相关性研究

目的:探讨鼻咽癌患者CT表现与血管内皮细胞生长因子以及p53蛋白表达的相关性.方法:选择经病理确诊的鼻咽癌患者36例,行螺旋CT扫描并采用免疫组化法检测肿瘤组织中VEGF和p53蛋白的表达,分析影像学特征与VEGF及p53蛋白表达的相关性.结果:鼻咽癌患者肿瘤组织中VEGF的表达与CT征象中的侵及后鼻孔、颅底骨质破坏及颈部淋巴结转移正相关,p53蛋白的表达与颈部淋巴结转移正相关.结论:肿瘤组织中VEGF和p53蛋白表达与鼻咽癌的部分CT影像学特征相关,可作为评价鼻咽癌CT表现恶性度及预后的指标.

The Relationship between CT Imaging and VEGF/p53 Protein Expression in Nasopharyngeal Carcinoma

Objective:To investigate the relationship between CT image features and vascular endothelial growth factor and p53 protein expression of patients with nasopharyngeal carcinoma.Methods:36 pathologically confirmed NPC patients were included in this study.All patients were scanned by spiral CT and the expression of VEGF/p53 protein in tumor tissue was detected by immunohistochemical method.The relationship between the imaging features and the expression of VEGF/p53 was analyzed.Results:The expression of VEGF is positively related with CT signs of invasion and choanal destruction of skull base and cervical lymph node metastasis.The expression of p53 protein is positively related with CT signs of cervical lymph node metastasis in nasopharyngeal carcinoma patients.Conclusion:The VEGF/p53 protein expression is related with the CT images characteristics in nasopharyngeal carcinoma.This could be a potential evaluation index of CT manifestations and prognosis.