北京中医药大学基础医学院

目的:通过对更年期抑郁症模型大鼠行为学以及学习记忆的观察,探讨中药复方更逍遥冲剂的作用机制 方法:SD雌性大鼠40只,随机分为假手术组、更年期抑郁症模型组、中药中剂量组、中药大剂量组和西药对照组,观察开野实验中大鼠活动度、强迫游泳中大鼠的不动时间、以及通道式水迷宫检测大鼠学习记忆能力.结果:模型大鼠经过21d治疗后,开野实验水平积分、垂直积分明显增加,强迫游泳不动时间缩短,水迷宫实验游出时间缩短,错误次数减少.结论:更逍遥冲剂能够明显的改善更年期抑郁症大鼠的行为学评分,并具有改善其学习记忆能力的作用.

Observation of the Effect of Gengxiaoyao Granule on Perimenopausal Depression Model Rats Behavior and Learning

Objective:To investigate the Gengxiaoyao Granule’s mechanism of action,through the observation of perimenopausal depression model rats behavior and learning.Methods:40 SD female rats,were randomly divided into sham operation group,model group,middle dose Chinese medicine group,high dose Chinese medicine group and Western medicine group;we observed rat activity in the open field test,the immobility time on forced swimming,and memory ability through channel type water maze.Results:Model of rat after treatment with 21d,level integration,vertical integration in the open field tests was significantly increased,immobility time of forced swimming was reduced;in channel type water maze experiment,travel time were significantly shortened,and the error time was reduced.Conclusion:Gengxiaoyao granule can obviously improve the behavior scores of perimenopausal depression rats,and has improved the ability of learning and memory.